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Genomic Signature of Oral Squamous Cell Carcinomas from Non-Smoking Non-Drinking Patients

1 Mar 2021

Abstract excerpt

Molecular alterations in 176 patients with oral squamous cell carcinomas (OSCC) were evaluated to delineate differences in non-smoking non-drinking (NSND) patients. Somatic mutations and DNA copy number variations (CNVs) in a 68-gene panel and human papilloma virus (HPV) status were interrogated using targeted next-generation sequencing. In the entire cohort, TP53 (60%) and CDKN2A (24%) were most frequently...

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PMID: 33804510
DOI: 10.3390/cancers13051029

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