Article
A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.
Molecular and cellular biology - 1 Feb 2014
Li Xiao Ling, Hara Toshifumi, Choi Youngeun, Subramanian Murugan, Francis Princy, Bilke Sven, Walker Robert L, Pineda Marbin, Zhu Yuelin, Yang Yuan, Luo Ji, Wakefield Lalage M, Brabletz Thomas, Park Ben Ho, Sharma Sudha, Chowdhury Dipanjan, Meltzer Paul S, Lal Ashish
Abstract excerpt
The tumor suppressor p21 acts as a cell cycle inhibitor and has also been shown to regulate gene expression by functioning as a transcription corepressor. Here, we identified p21-regulated microRNAs (miRNAs) by sequencing small RNAs from isogenic p21(+/+) and p21(-/-) cells. Three abundant miRNA clusters, miR-200b-200a-429, miR-200c-141, and miR-183-96-182, were downregulated in p21-deficient cells. Consistent...
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