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Article

Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia

11 Sept 2014

Abstract excerpt

Branching epithelial morphogenesis is closely linked to epithelial-to-mesenchymal transition (EMT), a process important in normal development and cancer progression. The miR-200 family regulates epithelial morphogenesis and EMT through a negative feedback loop with the ZEB1 and ZEB2 transcription factors. miR-200 inhibits expression of ZEB1/2 mRNA, which in turn can down-regulate the miR-200 family that further...

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PMID: 25216122
DOI: 10.3390/genes5030804

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