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Article

Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2013

Monk Jonathan M, Charusanti Pep, Aziz Ramy K, Lerman Joshua A, Premyodhin Ned, Orth Jeffrey D, Feist Adam M, Palsson Bernhard Ø

Abstract excerpt

Genome-scale models (GEMs) of metabolism were constructed for 55 fully sequenced Escherichia coli and Shigella strains. The GEMs enable a systems approach to characterizing the pan and core metabolic capabilities of the E. coli species. The majority of pan metabolic content was found to consist of alternate catabolic pathways for unique nutrient sources. The GEMs were then used to systematically analyze growth...

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Identifiers

PMID: 24277855
DOI: 10.1073/pnas.1307797110
PMCID: PMC3864276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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