Article
Antiretroviral therapy optimisation without genotype resistance testing: a perspective on treatment history based models.
PloS one - 29 Oct 2010
Prosperi Mattia C F, Rosen-Zvi Michal, Altmann André, Zazzi Maurizio, Di Giambenedetto Simona, Kaiser Rolf, Schülter Eugen, Struck Daniel, Sloot Peter, van de Vijver David A, Vandamme Anne-Mieke, Sönnerborg Anders
Abstract excerpt
BACKGROUND: Although genotypic resistance testing (GRT) is recommended to guide combination antiretroviral therapy (cART), funding and/or facilities to perform GRT may not be available in low to middle income countries. Since treatment history (TH) impacts response to subsequent therapy, we investigated a set of statistical learning models to optimise cART in the absence of GRT information. METHODS AND FINDINGS:...
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