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Article

Why genes evolve faster on secondary chromosomes in bacteria.

PLoS computational biology - 1 Apr 2010

Cooper Vaughn S, Vohr Samuel H, Wrocklage Sarah C, Hatcher Philip J

Abstract excerpt

In bacterial genomes composed of more than one chromosome, one replicon is typically larger, harbors more essential genes than the others, and is considered primary. The greater variability of secondary chromosomes among related taxa has led to the theory that they serve as an accessory genome for specific niches or conditions. By this rationale, purifying selection should be weaker on genes on secondary...

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PMID: 20369015
DOI: 10.1371/journal.pcbi.1000732
PMCID: PMC2848543

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