Article
Lifetime, untreated isolated GH deficiency due to a GH-releasing hormone receptor mutation has beneficial consequences on bone status in older individuals, and does not influence their abdominal aorta calcification.
Endocrine - 1 Sept 2014
Souza Anita H O, Farias Maria I T, Salvatori Roberto, Silva Gabriella M F, Santana João A M, Pereira Francisco A, de Paula Francisco J A, Valença Eugenia H O, Melo Enaldo V, Barbosa Rita A A, Pereira Rossana M C, Gois-Junior Miburge B, Aguiar-Oliveira Manuel H
Abstract excerpt
The GH/IGF-I axis has essential roles in regulating bone and vascular status. The age-related decrease in GH secretion ("somatopause") may contribute to osteoporosis and atherosclerosis, commonly observed in the elderly. Adult-onset GH deficiency (GHD) has been reported to be associated with reduced bone mineral density (BMD), increased risk of fractures, and premature atherosclerosis. We have shown the young...
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