Article
Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene.
The Journal of clinical endocrinology and metabolism - 1 Feb 2010
Aguiar-Oliveira Manuel H, Oliveira Francielle T, Pereira Rossana M C, Oliveira Carla R P, Blackford Amanda, Valenca Eugenia H O, Santos Elenilde G, Gois-Junior Miburge B, Meneguz-Moreno Rafael A, Araujo Vanessa P, Oliveira-Neto Luis A, Almeida Roque P, Santos Mário A, Farias Natalia T, Silveira Debora C R, Cabral Gabriel W, Calazans Flavia R, Seabra Juliane D, Lopes Tiago F, Rodrigues Endrigo O, Porto Livia A, Oliveira Igor P, Melo Enaldo V, Martari Marco, Salvatori Roberto
Abstract excerpt
CONTEXT: Reduced longevity observed in hypopituitarism has been attributed to GH deficiency (GHD). It is, however, unclear whether GHD or other confounding factors cause this early mortality. OBJECTIVE: The aim was to study longevity in subjects from a large kindred with untreated, lifetime isolated GHD (IGHD) due to a homozygous mutation in the GHRH receptor gene and in heterozygous carriers of the mutation....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.