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Article

IGF-I bioavailability in congenital isolated growth hormone deficiency.

European journal of endocrinology - 4 Feb 2026

Campos Viviane C, Aguiar Oliveira Manuel H, Bidlingmaier Martin, Yuen Kevin C J, Salvatori Roberto, Oliveira Carla R P, Leal Angela, Melo Enaldo, Schilbach Katharina, Frystyk Jan, Schweizer Júnia R O L

Abstract excerpt

BACKGROUND: The Itabaianinha cohort in Brazil carries a homozygous growth hormone-releasing hormone (GHRH) receptor (GHRH-R) gene mutation, causing congenital isolated GH deficiency (GHD). Affected individuals present with severe short stature, central obesity, hypercholesterolemia, and marked reductions in serum GH, IGF-I, and IGFBP 3 concentrations yet show no premature atherosclerosis and maintain a normal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41528724
DOI: 10.1093/ejendo/lvag007

Genes

STC2
GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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