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Article

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

Immunology - 1 Apr 2014

Siggs Owen M, Yates Adèle L, Schlenner Susan, Liston Adrian, Lesage Sylvie, Goodnow Christopher C

Abstract excerpt

Quantitative reductions in T-cell receptor (TCR) signalling are associated with severe immunodeficiency, yet in certain cases can lead to autoimmunity. Mutation of the tyrosine kinase ZAP-70 can cause either of these outcomes, yet the limits of its signal transducing capacity are not well defined. To investigate these limits we have made use of mrtless: a chemically induced mutation of Zap70 associated with...

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Source

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Identifiers

PMID: 24266404
DOI: 10.1111/imm.12220
PMCID: PMC3956432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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