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Article

Tumour induction by the retinoblastoma mutation is independent of N-myc expression.

Nature - 1 Jan 2000

Squire J, Goddard A D, Canton M, Becker A, Phillips R A, Gallie B L

Abstract excerpt

Retinoblastoma (RB) tumours form in the eyes of young children when homozygosity for a mutation at the Rb-1 locus develops in a somatic retinal cell. A similar shift to homozygosity for the RB mutation has been observed in osteogenic sarcoma (OS) tumours that commonly arise as second tumours in c...

Topics

Animals
Brain
Cell Line
Cells, Cultured
Fetus
Gene Expression Regulation
Genes, Regulator
Humans
Mice
Mice, Nude
Mutation
Nucleic Acid Hybridization
Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteosarcoma

RNA

Retina

Retinoblastoma

Source

Identifiers

PMID: 2426601
DOI: 10.1038/322555a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2426601-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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