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Article

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

12 Nov 2013

Abstract excerpt

Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells. We have established a Drosophila melanogaster model to study glycogen autophagy in skeletal muscles, using chloroquine (CQ) to simulate a vacuolar myopathy that is completely dependent on the...

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Share to Autophagy in Disease and Therapy
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PMID: 24265594
DOI: 10.1371/journal.pbio.1001708

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