Expression of Autophagy-Associated Genes in Skeletal Muscle: An Experimental Model of Chloroquine-Induced Myopathy

Abstract excerpt

OBJECTIVE: Chloroquine modulates autophagocytic protein degradation in the lysosome system, thereby inducing the formation of rimmed vacuoles consisting of autophagosomes and autolysosomes in skeletal muscle. The goal of this study was to investigate the contribution of the lysosomal system, particularly autophagosome formation (an autophagic process) at the molecular level, to the abnormal accumulation of...

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