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Article

The Contributions of HIF-Target Genes to Tumor Growth in RCC

18 Nov 2013

Abstract excerpt

Somatic mutations or loss of expression of tumor suppressor VHL happen in the vast majority of clear cell Renal Cell Carcinoma, and it's causal for kidney cancer development. Without VHL, constitutively active transcription factor HIF is strongly oncogenic and is essential for tumor growth. However, the contribution of individual HIF-responsive genes to tumor growth is not well understood. In this study we...

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Share to Cancer, Hypoxia, and Metabolism
Share to Hepatocellular Carcinoma Treatment and Prognosis
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PMID: 24260413
DOI: 10.1371/journal.pone.0080544

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