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Article

ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.

Journal of virology - 1 Feb 2014

Eduardo-Correia Benedito, Martínez-Romero Carles, García-Sastre Adolfo, Guerra Susana

Abstract excerpt

Conjugation of ISG15 inhibits replication of several viruses. Here, using an expression system for assaying human and mouse ISG15 conjugations (ISGylations), we have demonstrated that vaccinia virus E3 protein binds and antagonizes human and mouse ISG15 modification. To study ISGylation importance in poxvirus infection, we used a mouse model that expresses deconjugating proteases. Our results indicate that...

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Identifiers

PMID: 24257616
DOI: 10.1128/JVI.03293-13
PMCID: PMC3911545

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.PMID 24257616Read ↗

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Suppression of SARS-CoV-2 nucleocapsid protein dimerization by ISGylation and its counteraction by viral PLproSemantic proximity Read ↗

ISG15 is required for the dissemination of <i>Vaccinia virus</i> extracellular virionsSemantic proximity Read ↗

SARS-CoV-2 papain-like protease inhibits ISGylation of the viral nucleocapsid protein to evade host anti-viral immunitySemantic proximity Read ↗

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Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 ProteinSemantic proximity Read ↗

ISG15: leading a double life as a secreted moleculeSemantic proximity Read ↗

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