Article
Local control of hepatic phenotype with growth factor-encoded surfaces.
Integrative biology : quantitative biosciences from nano to macro - 1 Jan 2014
Patel Dipali, Haque Amranul, Jones Caroline N, Tuleouva Nazgul, Foster Elena, Vu Tam, Reddi A Hari, Revzin Alexander
Abstract excerpt
The goal of the present study was to modulate the phenotype expression of hepatocytes in vitro on surfaces imprinted with growth factors (GFs). Hepatocyte growth factor (HGF) or transforming-growth factor-β1 (TGF-β1) were mixed with collagen (I) and robotically printed onto standard glass slides to create arrays of 300 μm or 500 μm diameter spots. Primary rat hepatocytes were seeded on top of the arrays, forming...
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