Article
Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 1999
Bhatia S N, Balis U J, Yarmush M L, Toner M
Abstract excerpt
Heterotypic cell interaction between parenchymal cells and nonparenchymal neighbors has been reported to modulate cell growth, migration, and/or differentiation. In both the developing and adult liver, cell-cell interactions are imperative for coordinated organ function. In vitro, cocultivation of hepatocytes and nonparenchymal cells has been used to preserve and modulate the hepatocyte phenotype. We summarize...
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