Article

The role of hippocampal spatial representations in contextualization and generalization of fear

2019-01-09

Abstract excerpt

Using contextual information to predict aversive events is a critical ability that protects from generalizing fear responses to safe contexts. Animal models have demonstrated the importance of spatial context representations within the hippocampal formation in contextualization of fear learning. The ventromedial prefrontal cortex (vmPFC) is known to play an important role in safety learning, possibly also through...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76222bc4-b4cf-5733-b20c-ef4fa99d0eae
DOI: 10.1101/514505

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of hippocampal spatial representations in contextualization and generalization of fearDOI 10.1101/514505Read

The impact of cue learning, trait anxiety and genetic variation in the serotonin 1A receptor on contextual fear.Semantic proximity Read

Multiple-Context Training Enhances Generalization of Cued Fear Extinction and Requires the Dorsal HippocampusSemantic proximity Read

Context reexposure to bolster contextual dependency of emotional episodic memorySemantic proximity Read

High threat intensity increases conditioned fear generalization and makes extinction of a generalization stimulus less effectiveSemantic proximity Read

Expectation of aversive outcomes drives multimodal integration of behavioural, physiological and neural activations during human fear retrieval and generalisationSemantic proximity Read

Spreading the reduction of fear: A narrative review of generalization of extinction learning in human fear conditioningSemantic proximity Read

Spreading the reduction of fear: A narrative review of generalization of extinction learning in human fear conditioningSemantic proximity Read

The BDNF Val66Met polymorphism modulates the generalization of cued fear responses to a novel context.Semantic proximity Read

Systematically investigating the role of context on effect replicability in reinstatement of fear in humansSemantic proximity Read

Human fear acquisition deficits in relation to genetic variants of the corticotropin releasing hormone receptor 1 and the serotonin transporter.Semantic proximity Read

Spreading the reduction of fear: A systematic review on generalization of extinction learning in human fear conditioningSemantic proximity Read

Salient Safety Conditioning Improves Novel Discrimination LearningSemantic proximity Read