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Article

Distribution of the fittest individuals and the rate of Muller's ratchet in a model with overlapping generations.

PLoS computational biology - 1 Jan 2013

Metzger Jakob J, Eule Stephan

Abstract excerpt

Muller's ratchet is a paradigmatic model for the accumulation of deleterious mutations in a population of finite size. A click of the ratchet occurs when all individuals with the least number of deleterious mutations are lost irreversibly due to a stochastic fluctuation. In spite of the simplicity of the model, a quantitative understanding of the process remains an open challenge. In contrast to previous works,...

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Identifiers

PMID: 24244123
DOI: 10.1371/journal.pcbi.1003303
PMCID: PMC3820511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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