Diffusion approximations in population genetics and the rate of Muller's ratchet.

Abstract excerpt

The Wright-Fisher binomial model of allele frequency change is often approximated by a scaling limit in which selection, mutation and drift all decrease at the same 1/N rate. This construction restricts the applicability of the resulting 'Wright-Fisher diffusion equation' to the weak selection, weak mutation regime of evolution. We argue that diffusion approximations of the Wright-Fisher model can be used more...

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