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Article

LRRK2, GBA and SMPD1 Founder Mutations and Parkinson's Disease in Ashkenazi Jews.

Dementia and geriatric cognitive disorders - 1 Jan 2016

Dagan Efrat, Schlesinger Ilana, Kurolap Alina, Ayoub Mareemar, Nassar Maria, Peretz-Aharon Judith, Gershoni-Baruch Ruth

Abstract excerpt

BACKGROUND/AIM: Parkinson's disease (PD) is associated with mutations in LRRK2, GBA, and SMPD1 genes. We describe the clinical characteristics of PD patients related to their carrier status of the Ashkenazi founder mutations in the aforementioned genes. METHODS: Ashkenazi PD patients (n = 270) were recruited following informed consent, and tested for the founder Ashkenazi mutations in the above genes. Clinical...

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Identifiers

PMID: 27449028
DOI: 10.1159/000447450

Genes

SMPD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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