Article
Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.
Oncogene - 20 Nov 2014
Zaganjor E, Osborne J K, Weil L M, Diaz-Martinez L A, Gonzales J X, Singel S M, Larsen J E, Girard L, Minna J D, Cobb M H
Abstract excerpt
We show that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells (HBEC) by expression of K-Ras(G12V) and knockdown of p53. Further investigation demonstrates that this is due to the K-Ras/ERK1/2 MAPK pathway, as loss of p53 had little effect on KIF2C expression. In addition to KIF2C, we also found that the related kinesin KIF2A...
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