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Article

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice.

The Journal of pharmacy and pharmacology - 1 Dec 2013

Du Jing, Liang Yu, Xu Feng, Sun Bing, Wang Zhao

Abstract excerpt

OBJECTIVE: Alzheimer's Disease (AD) is well characterized by the accumulated Aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study and learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties and exhibited therapeutic effects in animal models of several neural degenerative disorders. However, the effect of trehalose on AD pathology...

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Source

Identifiers

PMID: 24236985
DOI: 10.1111/jphp.12108

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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