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Article

Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.

Journal of translational medicine - 9 Apr 2020

Santana Magda M, Paixão Susana, Cunha-Santos Janete, Silva Teresa Pereira, Trevino-Garcia Allyson, Gaspar Laetitia S, Nóbrega Clévio, Nobre Rui Jorge, Cavadas Cláudia, Greif Hagar, Pereira de Almeida Luís

Abstract excerpt

BACKGROUND: Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression. In this work we investigated whether trehalose, a natural occurring disaccharide widely used in food and cosmetic...

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Identifiers

PMID: 32272938
DOI: 10.1186/s12967-020-02302-2
PMCID: PMC7144062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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