Article
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.
Autophagy - 1 Sept 2013
Castillo Karen, Nassif Melissa, Valenzuela Vicente, Rojas Fabiola, Matus Soledad, Mercado Gabriela, Court Felipe A, van Zundert Brigitte, Hetz Claudio
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron disease with no current effective treatment. Accumulation of abnormal protein inclusions containing SOD1, TARDBP, FUS, among other proteins, is a pathological hallmark of ALS. Autophagy is the major degradation pathway involved in the clearance of damaged organelles and protein aggregates. Although autophagy has been shown to efficiently degrade ALS-linked...
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