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Article

Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Ibrahim Nor Faeizah, Yanagisawa Daijiro, Durani Lina Wati, Hamezah Hamizah Shahirah, Damanhuri Hanafi Ahmad, Wan Ngah Wan Zurinah, Tsuji Mayumi, Kiuchi Yuji, Ono Kenjiro, Tooyama Ikuo

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia. The cardinal neuropathological characteristic of AD is the accumulation of amyloid-β (Aβ) into extracellular plaques that ultimately disrupt neuronal function and lead to neurodegeneration. One possible therapeutic strategy therefore is to prevent Aβ aggregation. Previous studies have suggested that vitamin E analogs slow AD progression in humans. In...

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Identifiers

PMID: 27716672
DOI: 10.3233/JAD-160685
PMCID: PMC5147513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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