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Article

RhoE Is Regulated by Cyclic AMP and Promotes Fusion of Human BeWo Choriocarcinoma Cells

17 Jan 2012

Abstract excerpt

Fusion of placental villous cytotrophoblasts with the overlying syncytiotrophoblast is essential for the maintenance of successful pregnancy, and disturbances in this process have been implicated in pathological conditions such as pre-eclampsia and intra-uterine growth retardation. In this study we examined the role of the Rho GTPase family member RhoE in trophoblast differentiation and fusion using the BeWo...

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Share to Gestational Trophoblastic Disease Studies
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PMID: 22272352
DOI: 10.1371/journal.pone.0030453

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RhoE Is Regulated by Cyclic AMP and Promotes Fusion of Human BeWo Choriocarcinoma CellsPMID 22272352Read ↗

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HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4Semantic proximity Read ↗

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