Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes

6 Dec 2023

Abstract excerpt

Arrhythmogenic cardiomyopathy (AC) is an inherited disorder characterized by progressive loss of the ventricular myocardium causing life-threatening ventricular arrhythmias, syncope and sudden cardiac death in young and athletes. About 40% of AC cases carry one or more mutations in genes encoding for desmosomal proteins, including Desmoplakin (Dsp). We present here the first stable Dsp knock-out (KO) zebrafish...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Cardiovascular Effects of Exercise
Share to Genetics and Physical Performance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38057295
DOI: 10.1038/s41420-023-01741-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypesPMID 38057295Read ↗

Loss of cardiac Wnt/β-catenin signalling in desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological interventionSemantic proximity Read ↗

Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation.Semantic proximity Read ↗

In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal ModelsSemantic proximity Read ↗

Desmoplakin Cardiomyopathy: Gene Dose-Dependent Myocardial Remodeling, Arrhythmias, and Premature Death.Semantic proximity Read ↗

A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulationSemantic proximity Read ↗

<i>Dsp<sup>S311A</sup></i>knock-in mice replicate the clinical-pathological features of dominant and recessive forms of Desmoplakin-related cardiomyopathiesSemantic proximity Read ↗

Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathySemantic proximity Read ↗

Accelerated cardiac remodeling in desmoplakin transgenic mice in response to endurance exercise is associated with perturbed Wnt/β-catenin signaling.Semantic proximity Read ↗

Arrhythmogenic cardiomyopathy: pathology, genetics, and concepts in pathogenesis.Semantic proximity Read ↗

Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse modelSemantic proximity Read ↗

Established and Emerging Mechanisms in the Pathogenesis of Arrhythmogenic Cardiomyopathy: A Multifaceted DiseaseSemantic proximity Read ↗

PANoptosis is a prominent feature of desmoplakin cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.