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Article

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.

Cancer cell - 11 Nov 2013

Castellano Esther, Sheridan Clare, Thin May Zaw, Nye Emma, Spencer-Dene Bradley, Diefenbacher Markus E, Moore Christopher, Kumar Madhu S, Murillo Miguel M, Grönroos Eva, Lassailly Francois, Stamp Gordon, Downward Julian

Abstract excerpt

RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the development of RAS-driven tumors. However, it is unknown whether interaction of RAS with PI3-kinase is required in established tumors. The...

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Identifiers

PMID: 24229709
DOI: 10.1016/j.ccr.2013.09.012
PMCID: PMC3826036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24229709-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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