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Article

Systems Approaches to Modeling Chronic Mucosal Inflammation

1 Jan 2013

Abstract excerpt

The respiratory mucosa is a major coordinator of the inflammatory response in chronic airway diseases, including asthma and chronic obstructive pulmonary disease (COPD). Signals produced by the chronic inflammatory process induce epithelial mesenchymal transition (EMT) that dramatically alters the epithelial cell phenotype. The effects of EMT on epigenetic reprogramming and the activation of transcriptional...

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PMID: 24228254
DOI: 10.1155/2013/505864

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