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The Current and Future Landscape of SERCA Gene Therapy for Heart Failure: A Clinical Perspective

27 Apr 2015

Abstract excerpt

Gene therapy has been applied to cardiovascular disease for over 20 years but it is the application to heart failure that has generated recent interest in clinical trials. There is laboratory and early clinical evidence that delivery of sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) gene therapy is beneficial for heart failure and this therapy could become the first positive inotrope with anti-arrhythmic...

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PMID: 25914929
DOI: 10.1089/hum.2015.018

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