Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies.

doi:10.1158/1055-9965.EPI-13-0913

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Article

Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2014

Kitahara Cari M, Linet Martha S, Brenner Alina V, Wang Sophia S, Melin Beatrice S, Wang Zhaoming, Inskip Peter D, Freeman Laura E Beane, Braganza Melissa Z, Carreón Tania, Feychting Maria, Gaziano J Michael, Peters Ulrike, Purdue Mark P, Ruder Avima M, Sesso Howard D, Shu Xiao-Ou, Waters Martha A, White Emily, Zheng Wei, Hoover Robert N, Fraumeni Joseph F, Chatterjee Nilanjan, Yeager Meredith, Chanock Stephen J, Hartge Patricia, Rajaraman Preetha

Abstract excerpt

BACKGROUND: Brain glioma is a relatively rare and fatal malignancy in adulthood with few known risk factors. Some observational studies have reported inverse associations between diabetes and subsequent glioma risk, but possible mechanisms are unclear. METHODS: We conducted a pooled analysis of original data from five nested case-control studies and two case-control studies from the United States and China that...

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PMID: 24220915
DOI: 10.1158/1055-9965.EPI-13-0913
PMCID: PMC3947107

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