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CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

11 Nov 2013

Abstract excerpt

Cyclin-dependent kinases (CDKs) regulate a variety of fundamental cellular processes. CDK10 stands out as one of the last orphan CDKs for which no activating cyclin has been identified and no kinase activity revealed. Previous work has shown that CDK10 silencing increases ETS2 (v-ets erythroblastosis virus E26 oncogene homolog 2)-driven activation of the MAPK pathway, which confers tamoxifen resistance to breast...

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PMID: 24218572
DOI: 10.1073/pnas.1306814110

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