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Caspar Controls Resistance to Plasmodium falciparum in Diverse Anopheline Species

12 Mar 2009

Abstract excerpt

Immune responses mounted by the malaria vector Anopheles gambiae are largely regulated by the Toll and Imd (immune deficiency) pathways via the NF-kappaB transcription factors Rel1 and Rel2, which are controlled by the negative regulators Cactus and Caspar, respectively. Rel1- and Rel2-dependent transcription in A. gambiae has been shown to be particularly critical to the mosquito's ability to manage infection...

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PMID: 19282971
DOI: 10.1371/journal.ppat.1000335

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