Article
Risk for early pregnancy loss by factor XIII Val34Leu: the impact of fibrinogen concentration.
Journal of clinical laboratory analysis - 1 Nov 2013
Dossenbach-Glaninger Astrid, van Trotsenburg Mick, Oberkanins Christian, Atamaniuk Johanna
Abstract excerpt
BACKGROUND: We have already described a significantly elevated overall risk for recurrent pregnancy loss (RPL) in women carrying the coagulation factor XIII (FXIII) Val34Leu and/or the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism assuming that these polymorphisms contribute synergistically to RPL because of impaired hypofibrinolysis. Recent studies on FXIII indicate that the impact of the FXIII...
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