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Article

Genetic association of five plasminogen activator inhibitor-1 (PAI-1) polymorphisms and idiopathic recurrent pregnancy loss in Korean women.

Thrombosis and haemostasis - 1 Oct 2013

Jeon Young Joo, Kim Young Ran, Lee Bo Eun, Choi Yi Seul, Kim Ji Hyang, Shin Ji Eun, Rah HyungChul, Cha Sun Hee, Lee Woo Sik, Kim Nam Keun

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is important for maintaining pregnancy. Aberrantly increased PAI-1 levels may contribute to thrombosis and inflammation, leading to pregnancy loss. This study investigated the association of PAI-1 polymorphisms (PAI-1 rs2227631 [-844G>A], rs1799889 [-675 4G/5G], rs6092 [43G>A], rs2227694 [9785G>A], and rs7242 [11053T>G]) with idiopathic recurrent pregnancy loss (RPL) in...

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PMID: 23903286
DOI: 10.1160/TH13-03-0242

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