Article
Poor responses to tyrosine kinase inhibitors in a child with precursor B ‐cell acute lymphoblastic leukemia with SNX 2‐ ABL 1 chimeric transcript
11 Nov 2013
Abstract excerpt
In addition to BCR, various rare fusion partners for the ABL1 gene have been reported in leukemia. We have identified the fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), which has only once previously been reported in an adult patient. Cytogenetic analysis detected this fusion gene arising from a t(5;9)(q22;q34) translocation. ALL cells carrying a SNX2-ABL1 fusion exhibited a...
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