Article
Inhibition of Niemann-Pick-type C1-like1 by ezetimibe activates autophagy in human hepatocytes and reduces mutant α1-antitrypsin Z deposition.
Hepatology (Baltimore, Md.) - 1 Apr 2014
Yamamura Takeshi, Ohsaki Yuki, Suzuki Michitaka, Shinohara Yuki, Tatematsu Tsuyako, Cheng Jinglei, Okada Masato, Ohmiya Naoki, Hirooka Yoshiki, Goto Hidemi, Fujimoto Toyoshi
Abstract excerpt
UNLABELLED: Autophagy can degrade aggregate-prone proteins, but excessive autophagy can have adverse effects. It would be beneficial if autophagy could be enhanced in a cell type-specific manner, but this has been difficult because the basic mechanism of autophagy is common. In the present study we found that inhibition of Niemann-Pick-type C1-like 1 (NPC1L1) by ezetimibe activates autophagy only in hepatocytes...
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