Article
SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients.
PloS one - 1 Jan 2013
García-Bermúdez Mercedes, López-Mejías Raquel, Genre Fernanda, Castañeda Santos, González-Juanatey Carlos, Llorca Javier, Corrales Alfonso, Miranda-Filloy José A, Rueda-Gotor Javier, Gómez-Vaquero Carmen, Rodríguez-Rodríguez Luis, Fernández-Gutiérrez Benjamín, Pascual-Salcedo Dora, Balsa Alejandro, López-Longo Francisco J, Carreira Patricia, Blanco Ricardo, González-Álvaro Isidoro, Martín Javier, González-Gay Miguel A
Abstract excerpt
UNLABELLED: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. Previous genome-wide association studies have described SMAD3 rs17228212 polymorphism as an important signal associated with CV events. The aim of the present study was to evaluate for the first time the relationship between this gene...
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