Article
Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients.
PloS one - 1 Jan 2012
García-Bermúdez Mercedes, González-Juanatey Carlos, López-Mejías Raquel, Teruel María, Corrales Alfonso, Miranda-Filloy José A, Castañeda Santos, Balsa Alejandro, Fernández-Gutierrez Benjamín, González-Álvaro Isidoro, Gómez-Vaquero Carmen, Blanco Ricardo, Llorca Javier, Martín Javier, González-Gay Miguel A
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Since CD40-CD154 binding has direct consequences on inflammation process initiation, we aimed to replicate previous findings related to disease susceptibility in Spanish RA population. Furthermore, as the major complication in RA disease patients is the development of CV events due to...
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