Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis.

doi:10.1371/journal.pone.0106823

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Article

Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis.

PloS one - 1 Jan 2014

Genre Fernanda, López-Mejías Raquel, García-Bermúdez Mercedes, Castañeda Santos, González-Juanatey Carlos, Llorca Javier, Corrales Alfonso, Ubilla Begoña, Miranda-Filloy José A, Pina Trinitario, Gómez-Vaquero Carmen, Rodríguez-Rodríguez Luis, Fernández-Gutiérrez Benjamín, Balsa Alejandro, Pascual-Salcedo Dora, López-Longo Francisco J, Carreira Patricia, Blanco Ricardo, González-Álvaro Isidoro, Martín Javier, González-Gay Miguel A

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the general population. Several polymorphisms in the OPG gene with functional effects on cardiovascular disease in non-rheumatic individuals have been described. Therefore, we...

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PMID: 25184828
DOI: 10.1371/journal.pone.0106823
PMCID: PMC4153690

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