Article
Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2021
Barone Sharon, Zahedi Kamyar, Brooks Marybeth, Henske Elizabeth P, Yang Yirong, Zhang Erik, Bissler John J, Yu Jane J, Soleimani Manoocher
Abstract excerpt
Tuberous sclerosis complex (TSC) is caused by mutations in either TSC1 or TSC2 genes and affects multiple organs, including kidney, lung, and brain. In the kidney, TSC presents with the enlargement of benign tumors (angiomyolipomata) and cysts, which eventually leads to kidney failure. The factors promoting cyst formation and tumor growth in TSC are incompletely understood. Here, we report that mice with...
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