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Article

Acute environmental hypoxia induces LC3 lipidation in a genotype-dependent manner.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2014

Masschelein Evi, Van Thienen Ruud, D'Hulst Gommaar, Hespel Peter, Thomis Martine, Deldicque Louise

Abstract excerpt

Hypoxia-induced muscle wasting is a phenomenon often described with prolonged stays at high altitude, which has been attributed to altered protein metabolism. We hypothesized that acute normobaric hypoxia would induce a negative net protein balance by repressing anabolic and activating proteolytic signaling pathways at rest and postexercise and that those changes could be partially genetically determined. Eleven...

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PMID: 24200883
DOI: 10.1096/fj.13-239863

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SQSTM1

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