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Article

Stem cell programs are retained in human leukemic lymphoblasts.

Oncogene - 16 Apr 2015

Fan D, Zhou X, Li Z, Li Z-Q, Duan C, Liu T, Zhang F, Huang Y, Zhang Y, Gao F, Guo Y, Gupta R, Chen G, Enver T, Tang J, Hong D

Abstract excerpt

Leukemic lymphoblasts within different immunophenotypic populations possess stem cell properties. However, whether or not the self-renewal program is retained from stem cells or conferred on progenitors by leukemogenic molecules remains unknown. We have addressed the issue in the context of TEL-AML1-associated acute lymphoblastic leukemia (ALL) by profiling a refined program edited from genes essential for...

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PMID: 24909160
DOI: 10.1038/onc.2014.148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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