Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas.

doi:10.1038/modpathol.2012.109

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Article

Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2012

Nishino Michiya, Klepeis Veronica E, Yeap Beow Y, Bergethon Kristin, Morales-Oyarvide Vicente, Dias-Santagata Dora, Yagi Yukako, Mark Eugene J, Iafrate A John, Mino-Kenudson Mari

Abstract excerpt

Chromosomal rearrangements leading to constitutive activation of anaplastic lymphoma receptor tyrosine kinase (ALK) define a category of lung adenocarcinomas that may be amenable to targeted therapy with the ALK inhibitor crizotinib. Defining distinctive features of ALK-rearranged (ALK+) lung adenocarcinomas may help identify cases that merit molecular testing. However, data describing the morphologic features of...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
Adenocarcinoma, Papillary
Adult
Aged
Aged, 80 and over
Anaplastic Lymphoma Kinase
Antineoplastic Agents
Biopsy
Carcinoma, Signet Ring Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Crizotinib

Female

Gene Rearrangement

Genetic Predisposition to Disease

Humans

In Situ Hybridization, Fluorescence

Logistic Models

Lung Neoplasms

Source

Open in PubMed

Identifiers

PMID: 22743652
DOI: 10.1038/modpathol.2012.109

Genes

Provenance

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