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Article

Life without tRNAIle-lysidine synthetase: translation of the isoleucine codon AUA in Bacillus subtilis lacking the canonical tRNA2Ile.

Nucleic acids research - 1 Feb 2014

Köhrer Caroline, Mandal Debabrata, Gaston Kirk W, Grosjean Henri, Limbach Patrick A, Rajbhandary Uttam L

Abstract excerpt

Translation of the isoleucine codon AUA in most prokaryotes requires a modified C (lysidine or agmatidine) at the wobble position of tRNA2(Ile) to base pair specifically with the A of the AUA codon but not with the G of AUG. Recently, a Bacillus subtilis strain was isolated in which the essential gene encoding tRNA(Ile)-lysidine synthetase was deleted for the first time. In such a strain, C34 at the wobble...

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Identifiers

PMID: 24194599
DOI: 10.1093/nar/gkt1009
PMCID: PMC3919564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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