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Article

Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model

6 Nov 2013

Abstract excerpt

Using an in vivo cycling strategy, we selected metastatic cancer cells from the lymph nodes (LN) of mice bearing orthotopic DU145 human prostate tumors. Repeated rounds of metastatic selection (LN1-LN4) progressively increased the epithelial phenotype, resulting in a new model of tumor cell mesenchymal-epithelial transition (MET). DU145-LN4 showed increased cell-cell adhesions, higher expression of multiple...

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PMID: 24193225
DOI: 10.1038/srep03151

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