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Article

Epithelial-to-mesenchymal transition leads to disease-stage differences in circulating tumor cell detection and metastasis in pre-clinical models of prostate cancer.

Oncotarget - 15 Nov 2016

Lowes Lori E, Goodale David, Xia Ying, Postenka Carl, Piaseczny Matthew M, Paczkowski Freeman, Allan Alison L

Abstract excerpt

Metastasis is the cause of most prostate cancer (PCa) deaths and has been associated with circulating tumor cells (CTCs). The presence of ≥5 CTCs/7.5mL of blood is a poor prognosis indicator in metastatic PCa when assessed by the CellSearch® system, the "gold standard" clinical platform. However, ~35% of metastatic PCa patients assessed by CellSearch® have undetectable CTCs. We hypothesize that this is due to...

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Identifiers

PMID: 27764810
DOI: 10.18632/oncotarget.12682
PMCID: PMC5342801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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