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Article

Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes

5 Nov 2013

Abstract excerpt

Accurate chromosome segregation depends on coordination between cohesion resolution and kinetochore-microtubule interactions (K-fibers), a process regulated by the spindle assembly checkpoint (SAC). How these diverse processes are coordinated remains unclear. We show that in mammalian oocytes Shugoshin-like protein 2 (Sgol2) in addition to protecting cohesin, plays an important role in turning off the SAC, in...

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PMID: 24192037
DOI: 10.7554/elife.01133

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