Article
Epigenetic Control of the Vasopressin Promoter Explains Physiological Ability to Regulate Vasopressin Transcription in Dehydration and Salt Loading States in the Rat.
Journal of neuroendocrinology - 1 Apr 2016
Greenwood M P, Greenwood M, Gillard B T, Loh S Y, Paton J F R, Murphy D
Abstract excerpt
The synthesis of arginine vasopressin (AVP) in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus is sensitive to increased plasma osmolality and a decreased blood volume, and thus is robustly increased by both dehydration (increased plasma osmolality and decreased blood volume) and salt loading (increased plasma osmolality). Both stimuli result in functional remodelling of the SON...
Topics
- Animals
- Azacitidine
- Cell Line
- DNA (Cytosine-5-)-Methyltransferase 1
- DNA (Cytosine-5-)-Methyltransferases
- DNA Methylation
- DNA Methyltransferase 3A
- Decitabine
- Dehydration
- Demethylation
- Epigenesis, Genetic
- Hypothalamus
- Male